SkinMedica TNS Advanced+ Serum: Next-Generation Growth Factor Technology for Visible Anti-Aging Results

SkinMedica TNS Advanced+ Serum represents the next evolution of SkinMedica's legendary TNS growth factor technology — the gold standard that built the brand's reputation in physician-dispensed skincare. This skinmedica tns advanced+ serum builds upon the original TNS formula with TNS-MR, an advanced next-generation growth factor blend featuring an innovative peptide complex with balanced natural growth factors and cytokines that act on multiple levels of the skin simultaneously to deliver visibly transformative anti-aging results.

In a rigorous 24-week, double-blind, placebo-controlled clinical trial involving 68 men and women aged 37 to 70 with moderate to severe facial photodamage, TNS Advanced+ Serum demonstrated statistically significant improvements in wrinkling, skin texture, sagging, tone, and overall photodamage compared to placebo — with visible results starting as early as 2 weeks. In a separate 12-week study validated by a third-party psychometric scale, patients using TNS Advanced+ reported they looked up to 6 years younger. The serum's unique dual-chamber packaging keeps the two powerful formulas separated and stable until the moment of first use, ensuring maximum potency with every application.

Key Benefits

• Clinically proven significant improvement in wrinkling, texture, sagging, and tone starting at just 2 weeks
• Clinically proven to address sagging skin by week 8
• Patients reported looking up to 6 years younger after 12 weeks of use (validated by third-party psychometric scale)
• Progressive, cumulative results documented over a full 24-week clinical study
• Smooths the appearance of coarse wrinkles and fine lines
• Diminishes the appearance of dark spots and uneven skin tone
• Supports collagen and elastin production for firmer, more elastic-looking skin
• Innovative dual-chamber bottle preserves formula potency until first use
• Powered by TNS-MR — an advanced growth factor blend with a peptide complex of naturally balanced growth factors and cytokines
• Renessence (RSC) Advanced botanical blend supports and amplifies the growth factor results
• Suitable for daily morning and evening use as part of a complete anti-aging routine

Key Ingredients

• TNS-MR (Next-Generation Growth Factor Blend): An advanced complex containing human fibroblast conditioned media (naturally derived growth factors) along with two targeted peptides — Progeline (Trifluoroacetyl Tripeptide-2) for skin repair and Prolixir S20 (Dimer Tripeptide-43) for aging prevention — that work together to support skin renewal, collagen production, and cellular repair at multiple skin layers
• Lactococcus Ferment Lysate: A bioactive ferment shown to stimulate proteins that strengthen the skin's barrier, support epidermal thickness, and enhance the skin's natural renewal and barrier recovery process
• Whey Protein: Provides amino acids and nutrients that support skin repair processes and contribute to the overall renewing effect of the Renessence (RSC) Advanced blend
• Chlorella Vulgaris (Green Microalgae) Extract: A marine-derived botanical extract clinically recognized for supporting collagen and elastin levels — contributing to firmer, more resilient-looking skin over time
• Marine Extract (Spanish Marine Extract): Supports the skin's natural renewal processes, working synergistically with the growth factor blend to enhance overall skin rejuvenation
• Vitis Vinifera (Grape) Flower Cell Extract & Pyrus Malus (Apple) Fruit Extract: Botanical extracts that provide additional antioxidant support and contribute to the Renessence (RSC) Advanced formula's skin renewal benefits

• Apply twice daily — morning and evening — after cleansing and toning
• The dual-chamber bottle keeps the two formulas separated until first use — follow bottle instructions to combine before first application
• Dispense 1–2 pumps onto fingertips
• Apply evenly to face and neck, avoiding the immediate eye area
• Allow to fully absorb before applying moisturizer or additional skincare products
• Follow with a broad-spectrum SPF sunscreen during morning application
• For best results, use consistently twice daily — clinical studies show visible improvement starting at 2 weeks, with progressive results building through 24 weeks
• Can be layered with other SkinMedica products as part of a complete anti-aging regimen

Full Ingredient List: Aqua/Water/Eau, Pentylene Glycol, Human Fibroblast Conditioned Media, Glycereth-7 Triacetate, Shea Butter Ethyl Esters, Glycerin, Ethoxydiglycol, Lactococcus Ferment Lysate, Whey Protein, Chlorella Vulgaris Extract, Saccharide Isomerate, Dimer Tripeptide-43, Vitis Vinifera (Grape) Flower Cell Extract, Pyrus Malus (Apple) Fruit Extract, Hydroxyacetophenone, Tocopheryl Acetate, Propanediol, Xanthan Gum, Polyacrylate Crosspolymer-6, Polyacrylate-13, Polyisobutene, Sclerotium Gum, PEG-12 Dimethicone, Lecithin, Pullulan, Butylene Glycol, Sodium Citrate, Polysorbate 20, Aminomethyl Propanol, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin.

Please refer to product packaging for the most accurate and up-to-date full ingredient list. Contains human fibroblast conditioned media (growth factor technology) — consult your dermatologist before use if you have a history of skin cancer or other risk factors.

• BrandSkinMedica Product Type: Multi Peptide Growth Factor Anti-Aging Serum Volume: 1 fl. oz. / 28.4g Key Technology: TNS-MR Growth Factor Blend + Renessence (RSC) Advanced Key Ingredients: Human Fibroblast Conditioned Media, Progeline, Prolixir S20, Chlorella Vulgaris, Marine Extract Packaging: Innovative Dual-Chamber Bottle Usage Time: Morning & Evening (Twice Daily) Clinical Study: 24-Week Double-Blind, Placebo-Controlled Trial (68 Subjects, Ages 37-70) Clinical Results: Significant improvement at 2 weeks; sagging improvement at 8 weeks; up to 6 years younger appearance at 12 weeks Suitable For: Photodamaged, Aging, Mature Skin

Skin Type: Normal SkinDry SkinCombination SkinMature SkinPhotodamaged Skin

Skin Concern: Fine Lines and WrinklesCoarse WrinklesSagging SkinLoss of FirmnessUneven Skin ToneSkin TexturePhotodamageDark SpotsDullnessLoss of ElasticityPremature Aging